Social Epistemology & The University: Fuller argues that academic institutions should not treat knowledge as private property. Instead, he advocates for the democratization of knowledge, where science and higher education are publicly accountable and actively open to societal critique.

Humanity 2.0 & The Proactionary Imperative: Moving into the 21st century, his focus shifted toward transhumanism. He explores how genetic engineering, synthetic biology, and AI are actively redefining "the human". He champions a "proactionary" approach—embracing the risks of technological evolution to transcend our biological limits, rather than playing it safe.

The Post-Truth Condition: He famously reframes the "post-truth" era. Instead of a moral failing, Fuller views post-truth as a natural side effect of democratizing the media landscape. When traditional gatekeepers (like elite scientists and legacy journalists) lose their monopoly, everyone enters a "power game" to establish what is considered true.